We present a simulation-based approach to approximate the asymptotic variance and asymptotic distribution function of two-stage estimators. We focus on extremum estimators in the second stage and consider a large class of estimators in the first stage. This class includes extremum estimators, high-dimensional estimators, and other types of estimators (e.g., Bayesian estimators). We accommodate scenarios where the asymptotic distributions of both the first- and second-stage estimators are non-normal. We also allow for the second-stage estimator to exhibit a significant bias due to the first-stage sampling error. We introduce a debiased plug-in estimator and establish its limiting distribution. Our method is readily implementable with complex models. Unlike resampling methods, we eliminate the need for multiple computations of the plug-in estimator. Monte Carlo simulations confirm the effectiveness of our approach in finite samples. We present an empirical application with peer effects on adolescent fast-food consumption habits, where we employ the proposed method to address the issue of biased instrumental variable estimates resulting from the presence of many weak instruments.